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TriMix Injections help to solve mens issues with ED or Erectile Dysfunction. Erectile dysfunction is a  problem many men don’t want to think about, much less talk about.  However, it is increasingly common as men get older, and depending on the root cause(s) and severity, it can be devastating.  The ability to perform sexually often is tied to one’s own view of masculinity and self-worth.  While oral medications like Viagra have brought about a revolution in Erectile Dysfunction treatment, it is often insufficient for those with significant underlying physical conditions causing the Erectile Dysfunction. TriMix Shots may be your solution. TriMix cost is comparable to other ED treatments. Beware that some sites that allow you buy TriMix injections online do not offer a prescription. A prescription is required with TriMix. If you want to buy trimix injections online with a confidential telemedicine visit by phone, click the link below.

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Fortunately, there are TriMix Injections, a medical injection treatment for erectile dysfunction.  For many men who have tried other medications and methods of treating Erectile Dysfunction without success, TriMix Shots can often be a lifesaver – it is considered to be one of the most powerful types of erectile dysfunction treatments available today. TriMix cost is similar to other ED treatments. Also, Invigor Medical has made it easy for you to Buy Trimix Injections Online through our telemedicine network. Our TriMix cost is reasonable and our process is convenient.

Disclaimer – In all cases, patients are encouraged to talk to their medical practitioner about their issues and ask if TriMix Injections might be the best solution for them.  Your medical practitioner will know best.  Never undertake a treatment of injections of any kind, including TriMix Shots, unless you are under the care and supervision of a licensed doctor or other healthcare professional. When you buy TriMix injections online through Invigor Medical a phone consultation with one of our doctors is included. If TriMix Injections are right for you, you will receive a prescription and TriMix will be dispensed from our pharmacy. We will not process your payment until after we confirm that you qualify for Trimix Shots.

Basic Biology of Erectile Dysfunction (ED)

In order to fully understand what TriMix Injections are, how they works, and other related topics, it’s best to provide a quick refresher/crash-course on male reproductive system biology. Sexual arousal in a healthy male, without any Erectile Dysfunction, leads to a number of effects, the primary one for our purposes being the erection of the penis.  This is caused by signals from the brain and chemicals released by the body.  One key class of chemicals released are vasodilators, which relax and open the blood vessels and improve blood flow.  Coupled with various muscular and nerve reactions, blood flows into the penis and fills the spongy tissue that runs along the penile shaft.  The result is of this activity is an erection.

What Causes Erectile Dysfunction?

There are numerous ways for this basic biology to be disrupted, diminished, damaged, or altered.  The causes of Erectile Dysfunction can be psychological in nature, physiological, pharmacological, or idiopathic (a medical term meaning, essentially, unknown).

Psychological causes can usually be treated without medication through therapy or augmented with oral Erectile Dysfunction treatments.  These causes can include past mental trauma, anxiety, depression, and other mental health disorders.

Physiological conditions are more difficult to address.  A whole range of physical problems can make achieving an erection more difficult or impossible.  Chronic conditions like obesity, diabetes, heart problems, and blood pressure problems can contribute to Erectile Dysfunction.  Past physical trauma or extensive long-term pressure on the blood vessels supplying the penis can also cause diminished capacity – this is a common problem among cyclists.  Central nervous system injury, spinal injury, and other nerve-related problems can also result in decreased or absent erectile function.

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Buy TriMix Injections OnlinePharmacological causes can include the use of alcohol (a nervous system depressant) or illicit drugs.  Smoking has been known to decrease erectile function as well, both due to the effects on the heart, and the general sclerotic effects on blood vessels.  Perfectly legal, prescribed medications for medical conditions can also contribute to Erectile Dysfunction.  Many heart, blood pressure, and nervous system medications, including many mental health-related treatment medications, have various negative sexual side effects, that include decreased erectile function, delayed or absent ejaculatory reflex, difficulty maintaining an erection, and similar.

There are also cases where many of these avenues have been explored, and no clear root cause of a patient’s erectile dysfunction has been found.  This can be the most frustrating situation of all for men, having done their due diligence and seen doctors, been poked, prodded, and tested, and tried different approaches with no luck.  Fortunately, even in these cases, the option to buy TriMix Injections online may be a viable solution to restore some or all erectile function. TriMix cost can be cheaper through a non-US based TriMix compounding pharmacy but beware of bad side effects. When you buy TriMix injections online you will consult with a doctor by phone or Skype instead an awkward conversation with your family doctor.

What are TriMix Injections?

TriMix Injections are an injectable cocktail of medications designed to temporarily restore erectile function. TriMix cost is also relatively affordable. Three medications are combined in TriMix Shots (tri being the Latin prefix for three).  These medications are Papaverine, Prostaglandin, and Phentolamine. From a technical standpoint, they are classified as a vasodilator, a prostaglandin, and an alpha-adrenergic receptor antagonist, respectively.  We’ll cover each of these medications and what these terms mean in the following few sections.

Each of these medications on their own are often indicated for treating multiple unrelated health conditions. Combined in the proper ratios, however, they form a very powerful treatment for erectile dysfunction. Typical ratios for treatment are 30,000:10:1,000 or 30,000:20:2,000.  Put another way, Papaverine usually makes up 30 mg/mL of TriMix injection solution, Prostaglandin 10 mcg (micrograms)/mL of a solution, and Phentolamine 1 mg/mL, OR 30mg/mL, 20 mcg/mL, and 2 mg/mL, respectively as the other version typically offered. When you buy TriMix injections online though Invigor Medical you will receive all your TriMix Shots from a US based compounding pharmacy.

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Papaverine in TriMix Shots

Papaverine is a vasodilator – it relaxes and expands the blood vessels, allowing for an increase in blood flow. In practical terms, this helps increase blood flow to the penis, making it easier to achieve and maintain an erection.

The way in which this drug works to produce the vasodilation effect is complex.  For those interested in the science side of things, papaverine interacts with adenylate cyclase, an enzyme present in almost every cell of the body, which is responsible for triggering the conversion of ATP, adenosine triphosphate (the molecular energy chemical) into cAMP, cyclic adenosine monophosphate. The cAMP has a number of roles in the body in signaling, binding proteins to pass through the cell membrane, and other effects.  In this case, it ultimately inhibits phosphodiesterase, or PDE (specifically, PDE5).  PDE5 breaks down cGMP in the erectile tissue of the penis.  cGMP regulates blood flow in the penis.  Therefore, preventing or reducing the breakdown of cGMP by blocking the action of PDE5 results in more cGMP, correspondingly greater relaxation and blood flow in the penile arteries, veins, and erectile tissue.

This particular system of action, competitively inhibiting the action of PDE5, is also the method by which oral Erectile Dysfunction treatments like Viagra, Cialis, and Levitra (sildenafil, tadalafil, and vardenafil, respectively) and more recent analogues work.

In addition, there are other proposed methods and modes of action for papaverine, as cAMP plays many roles in the body, several of which may contribute to improving erectile function, but only the cAMP-cGMP-PDE5 inhibition route is well understood.  One proposed mechanism of action related to observed results from a study on dogs.  It was shown in this study that papaverine decreases the natural resistance to blood flow in the arteries, while increasing resistance in the veins.  In simple terms, and for our area of interest, this means it’s easier for blood to flow into the penile erectile tissue, and more difficult to leave – erections are therefore easier to achieve and easier to maintain.

Human studies with papaverine for erectile dysfunction treatment before the drug’s release were undertaken, as is customary to establish safety and efficacy for approval.

In one study, a group of 50 patients, ages 40 to 70, who were suffering from erectile dysfunction, were given injections on a bi-weekly basis of 60 mg of papaverine in a 5 mL saline solution, injected into the erectile tissue at the base of the penis (an intracavernosal injection).  98% of patients treated in this manner achieved an erection they rated as 80% of normal or better.

In another study, a group of 39 patients, ranging in age from 21 to 65 years old, were given a mixed intracavernosal injection of papaverine and phenoxybenzamine in saline solution.  Like the previous study, the dosage of papaverine was 60 mg, this time in a 10 mL saline solution with phenoxybenzamine.  A 100% restoration of erectile capacity occurred in 35% of study patients, with partial restoration in the remaining 65%.

Additional studies were conducted at lower TriMix Injection dosages, and in comparison, to oral Erectile Dysfunction treatments like sildenafil, with positive results for papaverine in all cases. when you buy TriMix injections Online through Invigor Medical you will receive TriMix Shots for an FDA approved compounding pharmacy based in the United States.

Prostaglandin in TriMix Shots

The second major component of TriMix Injections is prostaglandin E1, one of a class of substances known as prostaglandins.  Prostaglandins have hormone-like effects in the body.  They are not hormones, however, but rather are lipids synthesized from fatty acids in the body.    Prostaglandin E1 (also known as alprostadil) is a naturally-occurring substance that has numerous medical applications and uses.  In Erectile Dysfunction treatment, we are primarily focused on its vasodilation effects.  Much like papaverine, it helps in getting and maintaining an erection, by dilating blood vessels and supplying arteries in the penis.  It serves to increase the blood flow into the penis, and increase resistance to outflow via the veins, meaning more blood stays in the penis longer, thus making it easier to maintain an erection.

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As for the scientific side of things, prostaglandin E1, injected into the penis, is metabolized and broken down locally into compounds that have erectile-improving effects.  A secondary proposed mechanism of action is through changes to levels of noradrenaline.  However, this is not well understood.  The primary action, similar to papaverine, is through increased cAMP production, and the aforementioned chain that leads to increased muscle relaxation and vasodilation.  Because it is non-specific in effect, it should only be administered locally and is rarely if ever given systemically.  The majority is metabolized locally regardless of an injection site, and therefore injection to the penis results in the majority of active prostaglandin E1 being metabolized in the penis.

Prostaglandin E1 is considered a second-line medication for erectile dysfunction – that is, it should not be the first choice over oral PDE5 inhibiting drugs.  However, many of the studies that have been conducted to show that prostaglandin E1 is effective in at least improving erectile function in 40 to 70% of trial patients suffering from Erectile Dysfunction.  One of the reasons the medication is not the first choice has to do with the fact that some patients simply do not respond to prostaglandin.  The reason for this inconsistency is unknown.  However, prostaglandin combined with S-nitrosoglutathione seems to be more effective than prostaglandin alone, which is currently being investigated to explain some of this discrepancy.

In any event, this discrepancy means that prostaglandin E1 by itself is not the best choice for Erectile Dysfunction treatment.  Other medications in combination are therefore recommended, which is yet another reason why there are two other medications in TriMix Injections.  Nevertheless, because prostaglandin is a naturally-occurring substance in the body, and is so easily metabolized on a local level, there are few side effects, all relatively rare.  This makes it a safe choice for treatment, and combined with other proven Erectile Dysfunction medications, the synergistic effects can result in significant positive improvement for patients.

Phentolamine in TriMix Shots

Last but not least, TriMix Injections features a third medication known as phentolamine.  Phentolamine
has several effects, and while not directly being a vasodilator, it works similarly to the other medications discussed – relaxing muscles and dilating blood vessels.  It also increases cardiac output, and therefore blood flow.

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On a more specific scientific basis, phentolamine is known as an alpha-adrenoceptor antagonist.  Normally, the chemical noradrenaline circulating in the body keeps penile smooth muscle tissue contracted.  Alpha-adrenoceptors are the receptors for noradrenaline, and phentolamine, as an antagonist for these receptors, decreases the available binding sites for noradrenaline.  As a result, smooth muscles relax, promoting erection.  It is well-established that phentolamine binds to both types of alpha-adrenoceptors, competitively working with norepinephrine in the body to inhibit noradrenaline binding.  This is believed to be the main mechanism of action for phentolamine, though due to the complex nature of interaction with alpha-adrenoceptors, and corresponding action on the adrenergic nerves, it has not been definitively established.

Other mechanisms have also been proposed, including a nitric oxide activation through blocking of the 5-HT receptors, thus preventing histamine releases from mast cells.  The net result of this secondary mechanism of action is increased vasodilation.

Animal studies conducted prior to human trials of phentolamine showed a noticeable decrease in the resistance of arteries of the penis to blood inflow.  However, corresponding increases in resistance of veins to blood outflow is not present, which differentiates the effects of phentolamine from those of prostaglandin E1.  The exact pharmacokinetics are still poorly understood.

Metabolism of phentolamine occurs quickly, and therefore systemic administration for erectile dysfunction treatment is ineffective.  The half-life of the medication is around 30 minutes in human tissue, with the effects ranging from 2.5 to 4 hours in duration.

Human studies were also conducted, as required, prior to the approval of the medication.  In one study, 20 participants, ranging in age from 32 to 72, all suffering from impotence/erectile dysfunction, were treated with penile injections of 30 mg papaverine and 1 mg phentolamine.  In 18 or 20 subjects (90%), this produced an erection in 20 to 30 minutes that was deemed sufficient for intercourse.

Other studies of phentolamine had similar success, showing a marked increase in erectile function, especially in combination with other vasodilator and muscle relaxant drugs of the categories we have discussed in this article.  Therefore, it was approved for treatment of Erectile Dysfunction.

Phentolamine side effects are rare, though notably more serious than those of papaverine or prostaglandin E1. Adverse events include orthostatic hypotension (sudden low blood pressure upon standing), tachycardia (fast heart rate), arrhythmias (irregular heart rate), and in some cases, myocardial infarction (heart attack) have occurred following penile injection. Further studies have not demonstrated the medical or pharmacological basis for these adverse events.

TriMix Cost

TriMix cost can vary depending on the volume purchased. TriMix does not come in a standard one size fits all bottle but usually is dispensed in a 5ml and 10ml option. TriMix cost for from a US based TriMix compounding pharmacy without a prescription can range from $120 to $200 for a 5ml bottle. With a prescription included TriMix cost is roughly $220 to $300. One 5ml bottle of TriMix can last anywhere from 4 to 10 treatments depending on the need. This means the TriMix cost per treatment can range from approximately $22 to $55 per treatment with a 5ml bottle. Average TriMix cost is about $30 pretreatment with a prescription included. This means that the average TriMix cost per treatment is similar to other erectile dysfunction treatments. TriMix cost my be lower if buying overseas but beware of adverse side effects. Side effect from an injectable drug can be painful.

Side Effects of TriMix Injections

Now that you know about the medications in TriMix Shots, it’s important to understand the potential side effects of the injections.  Side effects are usually mild, though some typical Erectile Dysfunction treatment side effects can be serious and require medical attention.  Beware that purchased through a non-FDA approved TriMix compounding pharmacy TriMix cost may be cheaper but can possibly lead to severe side effects and infection. In general, mild to moderate pain during and immediately after the injection, at the injection site, is typical.  There may also be a transient painful sensation upon erection, and/or a small amount of bleeding at the injection site.  These are usually mild and go away quickly. If you are going to buy TriMix injections online make sure you buy them from a company with a certified doctor and dispense from a US based TriMix compounding pharmacy.

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Penile injections, of course, carry further risks due to the sensitive nature of the erectile tissue and structure of the penis.  These injections are delivered into the erectile tissue, the corpora cavernosa, and are known as intracavernosal injections.  Complications can sometimes occur, including redness, lumps, swelling, tenderness, or unusual curvature of the erect penis.  Any of these side effects with TriMix Shots are grounds to call your doctor or healthcare professional, though not immediate emergencies. This is just another great example of why you should use a company that has a doctor on staff if you want to buy TriMix injections online.

TriMix CostOn the other hand, like many Erectile Dysfunction treatments, there is a potential emergency situation that can develop with TriMix Shots.  Long-lasting erections that do not go away are serious, and typically erections lasting longer than 4 hours can cause serious and permanent damage to the penis. The prescribing literature states that erections lasting more than 2 hours should be treated with 2-4 30mg pseudoephedrine tablets by mouth, as well as an ice pack to the genitals.  If this does not resolve the erection within an hour, then emergency medical treatment is necessary.  This typically involves a shot of adrenaline or other chemicals to counteract the vasodilation and muscle relaxation and is generally far less painful than potentially damaging your penis permanently. TriMix cost may be cheaper when buying from a non TriMix compounding pharmacy but it may have additional adverse side effects. TriMix cost from an FDA approved US-based TriMix compounding pharmacy is still reasonable however.

Contraindications of TriMix Injections

  • There are also situations where TriMix Injections may be contraindicated by pre-existing health conditions, medications, or other factors.
  • If you are allergic or sensitive to any of the component medications in TriMix Injections, it should be avoided.
  • Any health conditions that result in a predisposition to developing priapism are contraindicated for TriMix Shots.
  • In addition, more serious health conditions such as sickle cell anemia, multiple myeloma, or leukemia should rule out TriMix Injections use.
  • Any deformities of the penis, penile implants, or past surgeries on the penis may be contraindicative for TriMix Shots treatment.
  • If you have been directed by your doctor or healthcare professional to abstain from sexual activity (for example, due to a heart condition), you should not use TriMix Injections.
  • Lastly, BE SURE TO TELL YOUR DOCTOR if you have a medical condition or are taking a medication that interferes with blood clotting, as this can lead to a dangerous and potentially life-threatening situation.

Precautions and Warnings of TriMix Injections

Prior to being prescribed TriMix Injections, you should provide your doctor or healthcare provider with a list of all of your medical conditions and all current medications you take.  This includes herbal or natural medications, over-the-counter and prescription drugs, dietary supplements, or other injectable products – any non-food, non-beverage items you consume as medication or supplements or inject.  This provides your doctor or healthcare provider with the information they need to ensure nothing you take will interact with the TriMix Injections. Alway buy TriMix from a TriMix compounding pharmacy. The TriMix cost of Invigor Medical is affordable and medications are effective.

TriMix Injection Storage

TriMix Injections should not be exposed to room temperature for long periods of time, as the mixture tends to break down.  It needs to be stored in a refrigerator between 36°F and 46°F (2° to 8°C).  While no negative effects, byproducts, or chemicals develop if these directions are not followed, the efficacy and potency of the medication are compromised, meaning the injections will essentially be less useful and/or may lose all efficacy entirely, thus negating their purpose.

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TriMix Shots, like all medications, should be kept out of reach of children and only used by the individual to whom it has been prescribed.  Do not share, sell, or redistribute your medication – it is a crime and dangerous. Unused medication should be disposed of in the trash, or, ideally, through a medication disposal program – many pharmacies and health care offices offer discreet and anonymous, safe medication disposal bins or kiosks.  DO NOT dispose of unused medication by flushing down the toilet, pouring down a drain, or introducing into the environment.

TriMix Injections Dosage and Frequency

If prescribed TriMix Injections for Erectile Dysfunction treatment, the most common forms are supplied as a liquid, with the active medications in a saline solution, usually in 5 mL vials. These are used for multiple injections. Dosage rates for a single injection should be between 0.05 cc and 0.2 cc, as determined by a doctor.  The exact rate will vary based on the level of erectile dysfunction, as well as any past history/testing of dosages.  As with most medications, doctors will start at the lowest dose, and work upwards with you over time to achieve the optimal effect.

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Dosage increases for triMix Shots should be done only with a minimum of 48 hours in between injections.  Increases in dosage should be no greater than 0.05 cc at a time. The maximum dose per injection should NEVER exceed 0.5 cc.

The reason for low dosages and steady, progressive increases, is to find the level of result that will work for you as an individual.  As dosage rate increases, the risk for dangerous, prolonged erections requiring emergency medical treatment increase as well.  There is little evidence of increased efficacy beyond the dosage level you find optimal for response, and the risk for prolonged erection requiring medical treatment increases exponentially beyond the maximum dosage limit.

As a result, you may not achieve significant results in initial dosages, but that should not discourage patients or deter them from using the product.  A steady increase in dosage, under medical supervision, until the optimal effect is reached, is the recommended course of treatment.

Under no circumstances should an extra or double dose be taken.  Used only as directed on the label instructions for your prescribed medication.

TriMix Injection Procedure

TriMix Injections should only be taken as directed by your doctor or healthcare provider, and as indicated on the prescribing label.  In general, this will indicate that injection should occur prior to the initiation of foreplay activities.  Intracavernosal injection with a clean syringe, in the dosage indicated, is the intended means of administration.  Your doctor may show you how to complete this kind of injection (often using safe saline rather than the medication in the demonstration).

When the injection directions are followed, erections typically are achieved within 5 to 20 minutes following injection and last for around one hour.  Again, erections lasting 2 hours or longer should be treated as per the instructions in the TriMix Shots Side Effects section.

Following injection, you should apply firm pressure at the injection site for approximately 5 minutes.  This will help prevent bruising, which can often become painful and may inhibit the very sexual activity you wish to facilitate with the medication treatment.

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TriMix Shots use should be limited to 2 times a week at most.  Optimal use should be at least 48 hours apart, but a minimum of 24 hours apart is required.  More frequent use can result in a much higher risk of negative side effects, including permanent damage to the penis.  This is largely due to the fact that, despite the effects of the medication wearing off, most medications are not fully eliminated from the body entirely for quite some time.  The 24-hour buffer, therefore, must be observed.

Your doctor or healthcare professional should demonstrate and advise you of how to complete the injections prior to ever attempting it yourself.  Proper handling, storage, and use of syringes should be demonstrated, in addition to the injection method.  As with any injection, there is a risk of needle breakage during the injection process. If a needle ever breaks during a self-injection, contact your doctor immediately.

Treatment Goals – The Optimal Outcome of a TriMix Shot

Despite the sometimes-off-putting side effects, warnings, and all the rest, TriMix Injections is a relatively safe product designed to do good – to provide men with the ability to achieve and maintain erections, restoring their virility, masculinity, and sex life – whether only with themselves or a partner.  TriMix cost is also relatively normal for and ED medication. It is not the first-choice treatment for Erectile Dysfunction, but one of the strongest, and if prescribed by a doctor, may very well be exactly what you need to solve your erectile dysfunction.

The overall goal of Erectile Dysfunction treatment with TriMix Shots is to find the correct, lowest possible dosage to provide you with an erection that you would rate as 100% of normal, sufficient for a satisfying sex life.  TriMix Shots are a last-resort option when therapy, oral medications, and other means have failed.  Nevertheless, when prescribed and used as directed, the majority of patients are able to safely use the product, and reliably achieve and maintain an erection for sexual activities. When you buy Trimix injections online with Invigor Medical you can be assured that you will receive excellent customer service. Out TriMix cost is also very competitive.

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Buy TriMix Injections Online | TriMix Injections (TriMix Shots) for Erectile Dysfunction 2018
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